Synthesis and Biological Evaluation of Novel Dihydro [2,3D] Pyridine Substituted Enaminosulfonamide Compounds as Potent Human Erythrocyte Carbonic Anhydrase II (hCAII)
نویسندگان
چکیده
Dihydro [2,3D] pyridine substituted enaminosulfonamide compounds have been synthesized and their effects on carbonic anhydrase II (hCAII) evaluated. Pyrido [2,3 d] pyrimidines were from barbituric acid derivatives, malonanitrile, aldehyde derivatives in basic condition then hydrolyzed with hydrochloric acid. The targeted syn-thesized amino sulfanilamide, dihydro compounds, triethylorthoformate. 1H NMR, 13C FT-IR elemental analysis used for the structural of compounds. half maximal inhibitory concentration (IC50) values determined to be between 27.03 104.39 μM hCA 19.85-76.64 Ki.
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ژورنال
عنوان ژورنال: Sakarya University Journal of Science
سال: 2021
ISSN: ['1301-4048', '2147-835X']
DOI: https://doi.org/10.16984/saufenbilder.688414